Jeff Bennett
Grandpa / Gaillard (voice), Dog (voice), Charlie (voice), Punky (voice), Fanman / Lenny (voice), Patient / Geezer / Workman (voice), Zan-Tar / Apeman #3 (voice)
Dee Bradley Baker
Nessie / Karl / Momsquatch (voice), Roccos / Audrey / Snail / Dinosaur (voice), Socko / Newspaper Guy (voice), Carrot / Seymour (voice), Lady Rainicorn / Snow Golem (voice), Duck / Tabby (voice), Señor Swampy / Turkey / Dolphins (voice)
Rob Paulsen
Danny / Tickle Monster (voice), Flavio (voice), HandyCat / Drillbit (voice), Solomon Fix (voice)
Kevin Michael Richardson
Krunch / Rastamon / Announcer / Alarm Clock (voice), Infinite Goliath / Hondo / Mechaneck (voice), Dad / Announcer / Zit / Applause Fish (voice), Ice Monster (voice)
Maurice LaMarche
Pickle Cop / Elecaptain Sam / Dog Catcher (voice), Bjorn / Working Troll #1 (voice), Birdsdorf / Apeman #1 (voice), Klemp (voice)
John DiMaggio
Jake / Ice Clops (voice), Mumpy (voice), Roy (voice)
John Kassir
Ice King / Fire Element (voice), Dugly Uckling / Kung Pao Bunny (voice), Bone / Soldier A / Soldier B / Soldier C (voice)
Annie Mumolo
Pixie / Little Prince / Munchie (voice), Melissa / Rusty / Patch (voice), Strikeout (voice)
Candi Milo
Bee (voice), Nurse Duckett (voice), Yumi / Octopus Dude (voice)
Charlie Schlatter
Chris (voice), Sugarfoot (voice), Willie / Gnome / Martin / Dwarf (voice)
S. Scott Bullock
Dr. Carnage / Timmy / Mr. Abbott (voice), Dorothy / Hummingbird (voice), Gi / Raffe / Co-Worker #2 (voice)
Aliki Theofilopoulos
Sweet Little Girl / Fortune Fish / Kid #1 (voice), Kelly / Mrs. Dusenberry (voice), Crimson (voice)
June Foray
Mall Walker / Old Man #1 / Man at Garbage Can (voice), Old Lady (voice)
Jessica DiCicco
Smart Alec / Plasma Tot (voice), Gloom / Fuzzy Animal (voice)
Billy West
Moobeard / Value Guy (voice), Finster #1 / Johnny Space Guy / Pilot #1 / Space Thug (voice)
Nika Futterman
Lulu (voice), Cathy (voice)
Chuck McCann
Navarro (voice), Buck (voice)
Charlie Adler
Finster #2 / Evil Leader / Pilot #2 / Space Thug (voice), Bossy LeCow / Raging Bullfrog (voice)
Colleen O'Shaughnessey
Tiffany / Mom (voice), Kit / Little Girl / Some Kid (voice)
Lloyd Floyd
Gary Guitar (voice), Fungus (voice)
Jennifer Hale
Ms. Penelope (voice), Victor's Mom / Express Mail / Co-Worker #3 (voice)
Tress MacNeille
Ma (voice), Mrs. Finster / Chicken #2 (voice)
Nancy Cartwright
Chum-Chum / Kid #1 (voice)
Keone Young
Flashback Lance / Flashback Zoopie (voice)
Kari Wahlgren
Sparkles / Mom / Leprechaun (voice)
Noah Nelson
Professor Brain Dog 7 (voice)
