Rob Paulsen
Crusading Chameleon (voice), The Forehead (voice), Brainchild / Charles (voice), Caped Chameleon (voice), Arthur (voice), Captain Mucilage (voice), The Terror (voice)
Pat Fraley
Carpeted Man (voice), Mayor Blank (voice), Mitch (voice), Bud Frontier / Carpeted Man (voice), Thrakkorzog's Tongue (voice), Zipperneck (voice), Dog Sidekick / Orangutan Sidekick (voice), The Carpeted Man (voice), Narrator (voice), Australopithecine (voice), Eastern Bloc Robot Cowboy (voice), Mayor Blank / Sgt. Doodlehead / Captain Sanity (voice), Visual Eye (voice)
Kevin Schon
Proto Clown / Feral Boy (voice), Big Shot (voice), Bigshot (voice), Jack Tuber (voice), Babyboomerangutan (voice), Feral Boy (voice), Watt (voice), Living Doll (voice)
Jim Cummings
Mr. Mental (voice), Joseph Stalin / Captain Decency (voice), Thrakkorzog (voice), Eyebrows Mulligan (voice), Stalingrad (voice), Barry the Tick (voice), Leonardo da Vinci / Mongol (voice), Owner (voice), Multiple Santa (voice)
Roger Rose
Four-Legged Man (voice), Skippy (voice), Brian Pinhead (voice)
Pat Musick
The Bee Twins / Sally Vacuum (voice), The Bee Twins (voice), Tuun-La Not Of This Earth (voice), Sally Vacuum (voice), Mad Nanny (voice), Fred (voice)
Maurice LaMarche
The Deadly Bulb (voice), Doorman / Evil Midnight Bomber (voice), Thrakkorzog's Roommate (voice), Hotel Manager (voice), Mr. Smarty Pants / Soren (voice), Human Ton / Handy (voice)
Dorian Harewood
Taft (voice), Pineapple Pokopo (voice), Golfer (voice), George Washington Carver (voice)
Danny Mann
Bellbot (voice), Dinosaur Neil (voice), Dr. Mung Mung / Tongue Tongue (voice), Mr. Exciting (voice)
Ed Gilbert
Idea Man (voice), Johannes Gutenberg (voice), El Seed (voice), El Seed / Indigestible Man (voice)
Tony Jay
Chairface Chippendale (voice)
Phil Proctor
Additional Voices (voice), Charles' Father (voice), Cordoroy Cordoba (voice)
Susan Silo
Jungle Janet / Jet Valkyrie (voice), Jungle Janet (voice), Jet Valkyrie / Johnny Omega (voice)
Jennifer Hale
Carmelita Vatos (voice), Carmelita Valos (voice)
Hamilton Camp
Professor Chromedome (voice), Benjamin Franklin (voice)
Steve Susskind
J.J. Eureka Vatos (voice), Rabbi (voice)
Paul Eiding
Socket (voice), Gezundtitan (voice)
Jennifer Darling
Mydna (voice), Mynda (voice)
Ron Feinberg
Santa Claus (voice), Omnipotus (voice)
Mary Kay Bergman
Ants / Secretary (voice), Ottoman (voice)
Brad Garrett
What Interrogator (voice), Jim Rage (voice)
Cynthia Songé
Grace (voice), Wheel (voice)
Peter Bergman
Terry (voice), Dennis (voice)
David Ossman
Coach (voice), Professor Peelie (voice)
